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3-Deazaadenosine hydrochloride 是 S-腺苷高半胱氨酸水解酶的抑制剂,Ki 值为 3.9 µM。 它具有抗炎、抗增殖和抗 HIV 活性。
3-Deazaadenosine hydrochloride 是 S-腺苷高半胱氨酸水解酶的抑制剂,Ki 值为 3.9 µM。 它具有抗炎、抗增殖和抗 HIV 活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,370 | 现货 | |
5 mg | ¥ 3,120 | 现货 | |
10 mg | ¥ 4,470 | 现货 | |
25 mg | ¥ 7,150 | 现货 | |
50 mg | ¥ 9,630 | 现货 | |
100 mg | ¥ 12,800 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 1,990 | 现货 |
产品描述 | 3-Deazaadenosine hydrochloride is an inhibitor of S-adenosylhomocysteine hydrolase (Ki: 3.9 μM). It has anti-inflammatory, anti-proliferative, and anti-HIV activity. |
靶点活性 | HIV-1 (A018 isolate):0.20 µM , HIV-1 (A012 isolate):0.15, S-adenosylhomocysteine hydrolase:(ki)3.9 µM |
体外活性 | 3-Deazaadenosine shows the anti-HIV effect and inhibits p24 antigen in peripheral blood mononuclear (PBMCs) cells infected with HIV-1 isolates (A012 and A018, IC50s: 0.15 and 0.20 μM) [1]. 3-Deazaadenosine (1-100 μM) inhibits LPS-induced expression of TNF-α mRNA, increases DNA binding activity of NF-κB, and causes proteolytic degradation of IκBα, but Not IκBβ in RAW 264.7 cells. 3-Deazaadenosine (100 μM) enhances the nuclear translocation of NF-κB but blocks LPS-induced NF-κB transcriptional activity, and such inhibition is augmented by the addition of homocysteine [2]. 3-Deazaadenosine (50, 100 μM) dose-dependently inhibits the phosphorylation of Raf and ERK, protein-dependent kinase 1, protein kinase B (Akt), and forkhead transcription factor FoxO1a. 3-Deazaadenosine (50 μM) suppresses vascular smooth muscle cell (VSMC) proliferation via interfering with Ras signaling [3]. |
细胞实验 | The HIV-1 strains A012 and A018 are used in the assay. Inhibition of p24 antigen is measured. Briefly, PHA-stimulated peripheral blood mononuclear (PBMCs) are incubated with either HIV-1 strain for 1 h at 37°C at 200-fold the 50% tissue culture infectious dose (TCID50) of the virus stock per 2 × 10^5 PBMC cells. The TCID50 is defined as the amount of virus stock at which 50% of the inoculated wells are positive. Cells are then grown in microtiter plates with different drug concentrations at 2 × 10^5 cells per well. On day 4, cells are resuspended and split 1:3 with fresh media and 3-Deazaadenosine. Supernatant p24 antigen is determined on day 7 by ELISA [1]. |
分子量 | 302.71 |
分子式 | C11H15ClN4O4 |
CAS No. | 86583-19-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 40.67 mg/mL (134.35 mM) H2O: 20 mg/mL | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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